STARmap PLUS is a new spatial gene mapping method combined with histological staining. With STARmap PLUS, we created high-resolution, comprehensive maps of altered molecular pathways and reactive cells in a mouse model of Alzheimer’s disease. These maps enabled us to infer the trajectories of biological processes and cell states during disease progression.
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Busche, M. A. & Hyman, B. T. Synergy between amyloid-β and tau in Alzheimer’s disease. Nat. Neurosci. 23, 1183–1193 (2020). This article reviews amyloid-β and tau in AD.
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This is a summary of: Zheng, H. et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01251-x (2023).
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Precise mapping of molecular and cellular brain changes in Alzheimer’s disease. Nat Neurosci 26, 371–372 (2023). https://doi.org/10.1038/s41593-023-01254-2