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Precise mapping of molecular and cellular brain changes in Alzheimer’s disease

STARmap PLUS is a new spatial gene mapping method combined with histological staining. With STARmap PLUS, we created high-resolution, comprehensive maps of altered molecular pathways and reactive cells in a mouse model of Alzheimer’s disease. These maps enabled us to infer the trajectories of biological processes and cell states during disease progression.

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Fig. 1: Cellular and molecular changes in the spatiotemporal context of disease pathology.


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This is a summary of: Zheng, H. et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nat. Neurosci. (2023).

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Precise mapping of molecular and cellular brain changes in Alzheimer’s disease. Nat Neurosci 26, 371–372 (2023).

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