By integrating ongoing bioethical collaboration, neuroscientists can create a positive effect on their research and the knowledge it produces. To this end, we offer our experiences with an interdisciplinary model for the ethical advancement of a promising area of neuroscience — human neural organoid research.
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This project was funded by the NIH BRAIN Initiative Grant no. RF1 MH117803. I.H and J.E.L. received additional funding from the Greenwall Foundation’s ‘Making a Difference’ Grant.
A.H.M.N. and P.K. are inventors on patents filed by the Presidents and Fellows of Harvard College and GC Therapeutics, Inc., and are co-founders of and have equity in GC Therapeutics, Inc. I.H. is a bioethics advisor for Bayer, the Novo Nordisk Foundation, and Rumi Therapeutics. P.A. is a member of the scientific advisory board at Herophilus, Rumi Therapeutics, and Foresite Labs, and is a co-founder of Vesalius. M.A.S.-S. and A.L. have submitted a patent application associated with engineered brain organoids (US Provisional Application Serial No. 63/048,502, filed July 6, 2020). Stanford University holds patents for the generation of cortical organoids/spheroids and assembloids (listing S.P.P. as an inventor). From September 1, 2021, M.P. has been an employee of Roche. G.M.C.’s competing interests are listed at https://arep.med.harvard.edu/gmc/tech.html. The remaining authors declare no competing interests.
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Hyun, I., Scharf-Deering, J.C., Sullivan, S. et al. How collaboration between bioethicists and neuroscientists can advance research. Nat Neurosci 25, 1399–1401 (2022). https://doi.org/10.1038/s41593-022-01187-2