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NEUROGENOMICS

Modeling PTSD neuronal stress responses in a dish

How genetic and environmental risk factors interact to trigger the development of post-traumatic stress disorder (PTSD) remains largely unknown. Seah et al. model stress hypersensitivity as a potential mechanism by examining transcriptomic responses to glucocorticoids in neurons derived from individuals with PTSD.

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Fig. 1: Modelling PTSD gene–environment interactions using PBMCs and iPS cell-derived glutamatergic NGN2-induced neurons.

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Correspondence to Jubao Duan.

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Zhang, S., Sanders, A.R. & Duan, J. Modeling PTSD neuronal stress responses in a dish. Nat Neurosci 25, 1402–1404 (2022). https://doi.org/10.1038/s41593-022-01172-9

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