Learning requires new oligodendrogenesis, but how myelin patterns change during learning is unclear. Bacmeister et al. show that motor learning induces phase-specific changes in myelination on behaviorally activated axons that correlate with motor performance, suggesting myelin remodeling is involved in learning.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
Cell & Bioscience Open Access 16 January 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Xin, W. & Chan, J. R. Nat. Rev. Neurosci. 21, 682–694 (2020).
Bacmeister, C. M. et al. Nat. Neurosci. 23, 819–831 (2020).
Cullen, C. L. et al. Cell Rep. 34, 108641 (2021).
Bacmeister, C. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01169-4 (2022).
McKenzie, I. A. et al. Science 346, 318–322 (2014).
Xu, T. et al. Nature 462, 915–919 (2009).
Roth, R. H. et al. Neuron 105, 895–908.e5 (2020).
Rasband, M. N. & Peles, E. Nat. Rev. Neurosci. 22, 7–20 (2021).
Zonouzi, M. et al. Cell Rep. 27, 2799–2808.e3 (2019).
Gibson, E. M. et al. Science 344, 1252304 (2014).
Mitew, S. et al. Nat. Commun. 9, 306 (2018).
Yang, S. M., Michel, K., Jokhi, V., Nedivi, E. & Arlotta, P. Science 370, eabd2109 (2020).
Acknowledgements
This work was supported by the National Institutes of Health/National Institute of Neurological Disorders and Stroke/National Institute for Mental Health (grants R01NS115746 and R01MH125515 to J.R.C. and grant F32NS116214 to W.X.), the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (APND grant A130141 to J.R.C.), and the Rachleff Family Endowment.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Xin, W., Chan, J.R. Motor learning revamps the myelin landscape. Nat Neurosci 25, 1251–1252 (2022). https://doi.org/10.1038/s41593-022-01156-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-022-01156-9
This article is cited by
-
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
Cell & Bioscience (2023)