Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Cortical norepinephrine GRABs a seat at the sleep table

A new study shows that infra-slow cortical norepinephrine oscillations shape the micro-structure of sleep and transitions to micro-arousals, wakefulness or rapid eye movement (REM) sleep. Prolonged descending phases of these oscillations promote the occurrence of spindle-rich intermediate sleep, which is involved in memory consolidation.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic representation of sleep architecture orchestration by NE-mediated mPFC activity.


  1. Poe, G. R. et al. Nat. Rev. Neurosci. 21, 644–659 (2020).

    Article  CAS  Google Scholar 

  2. Mitchell, H. A. & Weinshenker, D. Biochem. Pharmacol. 79, 801–809 (2010).

    Article  CAS  Google Scholar 

  3. Bonnet, M. H. & Arand, D. L. Sleep. Med. Rev. 7, 297–310 (2003).

    Article  Google Scholar 

  4. Watson, B. O., Levenstein, D., Greene, J. P., Gelinas, J. N. & Buzsáki, G. Neuron 90, 839–852 (2016).

    Article  CAS  Google Scholar 

  5. Kjaerby, C. et al. Nat. Neurosci. (2022).

    Article  PubMed  Google Scholar 

  6. Osorio-Forero, A., Cherrad, N., Banterle, L., Fernandez, L. M. J. & Lüthi, A. Int. J. Mol. Sci. 23, 5028 (2022).

    Article  CAS  Google Scholar 

  7. Wu, Z., Lin, D. & Li, Y. Nat. Rev. Neurosci. 23, 257–274 (2022).

    Article  CAS  Google Scholar 

  8. Eschenko, O., Magri, C., Panzeri, S. & Sara, S. J. Cereb. Cortex 22, 426–435 (2012).

    Article  Google Scholar 

  9. Osorio-Forero, A. et al. Curr. Biol. 31, 5009–5023.e7 (2021).

    Article  CAS  Google Scholar 

  10. Hayat, H. et al. Sci. Adv. 6, eaaz4232 (2020).

    Article  CAS  Google Scholar 

  11. Peyrache, A. & Seibt, J. Philos. Trans. R. Soc. Lond. B 375, 20190230 (2020).

    Article  Google Scholar 

  12. Dickey, C. W. et al. Nat. Commun. 12, 1027 (2021).

    Article  CAS  Google Scholar 

  13. Lecci, S. et al. Sci. Adv. 3, e1602026 (2017).

    Article  Google Scholar 

  14. Glin, L. et al. Physiol. Behav. 50, 951–953 (1991).

    Article  CAS  Google Scholar 

  15. Lustenberger, C. et al. Curr. Biol. 26, 2127–2136 (2016).

    Article  CAS  Google Scholar 

Download references


This work was funded by the Fyssen Foundation and an EMBO post-doctoral fellowhip (J.F.M.), an ATIP-Avenir grant, Emergence(s) Ville de Paris, a NARSAD BBRF Young Investigator Award and the FSER (Fondations Schlumberger pour la Recherche et l’Education) (G.G.).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gabrielle Girardeau.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Morici, J.F., Girardeau, G. Cortical norepinephrine GRABs a seat at the sleep table. Nat Neurosci 25, 978–980 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing