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Adolescent sleep molds adult social preferences

Sleep disruption is a common but poorly understood feature of neurodevelopmental disorders including autism spectrum disorder. A study by Bian et al. reveals that sleep disruption in adolescent mice leads to long-lasting changes in social novelty preferences. Importantly, these perturbations can be restored through balanced actions in midbrain dopamine systems.

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Fig. 1: Adolescent sleep shapes adult social preferences and dopamine systems.


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Correspondence to Jenna A. McHenry.

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McHenry, J.A. Adolescent sleep molds adult social preferences. Nat Neurosci 25, 841–843 (2022).

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