Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Robust adult neurogenesis in the primate hippocampus

The extent to which neurogenesis occurs in adult primates is still controversial. Single-cell RNA sequencing, immunofluorescence staining, and ex vivo neurosphere culture experiments were performed using the adult macaque hippocampus. The results reveal robust adult neurogenesis in the dentate gyrus of the primate hippocampus.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Adult neurogenesis in macaque hippocampus.


  1. Gonçalves, J. T., Schafer, S. T. & Gage, F. H. Adult neurogenesis in the hippocampus: from stem cells to behavior. Cell 167, 897–914 (2016). A Review article that presents all aspects of adult neurogenesis.

    Article  Google Scholar 

  2. Spalding, K. L. et al. Dynamics of hippocampal neurogenesis in adult humans. Cell 153, 1219–1227 (2013). Reports adult neurogenesis in humans using augmented 14C level.

    CAS  Article  PubMed Central  Google Scholar 

  3. Song, J., Olsen, R. H. J., Sun, J., Ming, G.-L. & Song, H. Neuronal circuitry mechanisms regulating adult mammalian neurogenesis. Cold Spring Harbor Persp. Biol. 8, a018937 (2016). A Review of the integration of adult newborn neurons into hippocampal circuits.

    Article  Google Scholar 

  4. Eriksson, P. S. et al. Neurogenesis in the adult human hippocampus. Nat. Med. 4, 1313–1317 (1998). Reports adult neurogenesis in humans for the first time.

    CAS  Article  Google Scholar 

  5. Hochgerner, H., Zeisel, A., Lönnerberg, P. & Linnarsson, S. Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing. Nat. Neurosci. 21, 290–299 (2018). Identifies all key neural precursor populations in scRNA-seq datasets from mice at various ages.

    CAS  Article  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Hao, Z.-Z. et al. Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations. Nat. Neurosci. (2022).

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Robust adult neurogenesis in the primate hippocampus. Nat Neurosci 25, 684–685 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing