The extent to which neurogenesis occurs in adult primates is still controversial. Single-cell RNA sequencing, immunofluorescence staining, and ex vivo neurosphere culture experiments were performed using the adult macaque hippocampus. The results reveal robust adult neurogenesis in the dentate gyrus of the primate hippocampus.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gonçalves, J. T., Schafer, S. T. & Gage, F. H. Adult neurogenesis in the hippocampus: from stem cells to behavior. Cell 167, 897–914 (2016). A Review article that presents all aspects of adult neurogenesis.
Spalding, K. L. et al. Dynamics of hippocampal neurogenesis in adult humans. Cell 153, 1219–1227 (2013). Reports adult neurogenesis in humans using augmented 14C level.
Song, J., Olsen, R. H. J., Sun, J., Ming, G.-L. & Song, H. Neuronal circuitry mechanisms regulating adult mammalian neurogenesis. Cold Spring Harbor Persp. Biol. 8, a018937 (2016). A Review of the integration of adult newborn neurons into hippocampal circuits.
Eriksson, P. S. et al. Neurogenesis in the adult human hippocampus. Nat. Med. 4, 1313–1317 (1998). Reports adult neurogenesis in humans for the first time.
Hochgerner, H., Zeisel, A., Lönnerberg, P. & Linnarsson, S. Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing. Nat. Neurosci. 21, 290–299 (2018). Identifies all key neural precursor populations in scRNA-seq datasets from mice at various ages.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Hao, Z.-Z. et al. Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01073-x (2022).
Rights and permissions
About this article
Cite this article
Robust adult neurogenesis in the primate hippocampus. Nat Neurosci 25, 684–685 (2022). https://doi.org/10.1038/s41593-022-01075-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-022-01075-9
