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Parkinson’s disease in the single-cell era

Degeneration of dopaminergic neurons in the substantia nigra is a pathological hallmark of Parkinson’s disease (PD). However, not all dopamine-producing neurons degenerate. Kamath, Abdulraouf et al. find that there are ten transcriptionally defined dopaminergic subpopulations in the human substantia nigra, but only one carries significant PD genetic risk and is vulnerable to neurodegeneration in PD.

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Fig. 1: Scheme of the molecular anatomy of the human substantia nigra pars compacta.


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Correspondence to Ernest Arenas.

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Arenas, E. Parkinson’s disease in the single-cell era. Nat Neurosci 25, 536–538 (2022).

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