Activity-regulated myelination adaptively tunes neural circuit function in health. In rodent models of generalized epilepsy, recurrent seizures aberrantly increase myelination specifically within the seizure circuit. Blocking this seizure-induced myelination abrogates the progressive increase in seizure burden and ictal hypersynchrony that occurs in mice with intact activity-regulated myelination, indicating that maladaptive myelination can contribute to disease progression in epilepsy.
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This is a summary of: Knowles, J. K. et al. Maladaptive myelination promotes generalized epilepsy progression. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01052-2 (2022)
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Maladaptive myelination promotes seizure progression in generalized epilepsy. Nat Neurosci 25, 539–540 (2022). https://doi.org/10.1038/s41593-022-01053-1
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DOI: https://doi.org/10.1038/s41593-022-01053-1
