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A new player in neural circuits of emotions

Positive and negative valence are encoded in specific neural populations of the basolateral amygdala, but only few of these populations have been characterized. A new study identifies a novel population, defined by the molecular marker Fezf2, and demonstrates that two of its output pathways differentially encode emotional valence.

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Fig. 1: Divergent signaling for positive and negative valence in Fezf2-expressing neurons in the amygdala.


  1. 1.

    Lange, C. G., & James, W. The Emotions Vol. 1, 135 (Williams & Wilkins Co, 1922);

  2. 2.

    Pignatelli, M. & Beyeler, A. Curr. Opin. Behav. Sci. 26, 97–106 (2019).

    Article  Google Scholar 

  3. 3.

    Zhang, X., Guan, W., Yang, T. & Li, B. Nat. Neurosci. (2021).

  4. 4.

    Kim, J., Pignatelli, M., Xu, S., Itohara, S. & Tonegawa, S. Nat. Neurosci. 19, 1636–1646 (2016).

    CAS  Article  Google Scholar 

  5. 5.

    Beyeler, A. et al. Neuron 90, 348–361 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    O’Neill, P.-K., Gore, F. & Salzman, C. D. Curr. Opin. Neurobiol. 49, 175–183 (2018).

    Article  Google Scholar 

  7. 7.

    Beyeler, A. et al. Cell Rep. 22, 905–918 (2018).

    CAS  Article  Google Scholar 

  8. 8.

    Namburi, P. et al. Nature 520, 675–678 (2015).

    CAS  Article  Google Scholar 

  9. 9.

    Stuber, G. D. et al. Nature 475, 377–380 (2011).

    CAS  Article  Google Scholar 

  10. 10.

    Zhang, X., Kim, J. & Tonegawa, S. Neuron 105, 1077–1093.e7 (2020).

    CAS  Article  Google Scholar 

  11. 11.

    Shen, C.-J. et al. Nat. Med. 25, 337–349 (2019).

    CAS  Article  Google Scholar 

  12. 12.

    Lodato, S. et al. Nat. Neurosci. 17, 1046–1054 (2014).

    CAS  Article  Google Scholar 

  13. 13.

    Zuccotti, A., Magueresse, C. L., Chen, M., Neitz, A. & Monyer, H. Proc. Natl Acad. Sci. USA 111, 10726–10731 (2014).

    CAS  Article  Google Scholar 

  14. 14.

    Felix-Ortiz, A. C. et al. Neuron 79, 658–664 (2013).

    CAS  Article  Google Scholar 

  15. 15.

    Daviu, N., Bruchas, M. R., Moghaddam, B., Sandi, C. & Beyeler, A. Neurobiol. Stress 11, 100191 (2019).

    Article  Google Scholar 

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Correspondence to Anna Beyeler.

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Ju, A., Beyeler, A. A new player in neural circuits of emotions. Nat Neurosci 24, 1506–1507 (2021).

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