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BRAIN DEVELOPMENT

Placental signaling influences cerebellum development

Nature Neuroscience volume 24, pages 1343–1345 (2021)Cite this article

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Placental allopregnanolone affects oligodendrocyte differentiation and myelination in the developing cerebellum. Male mice deprived of allopregnanolone in utero show impaired sociability and communication in later life; their female littermates are unaffected. Allopregnanolone replacement restores normal myelination and behavior.

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Fig. 1: Placental allopregnanolone acts on the cerebellum in male fetuses.

References

  1. Vacher, C.-M. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-021-00896-4 (2021).

    Article  PubMed  Google Scholar 

  2. Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L. & Paul, S. M. Science 232, 1004–1007 (1986).

    Article  CAS  Google Scholar 

  3. Robel, P. & Baulieu, E. E. Crit. Rev. Neurobiol. 9, 383–394 (1995).

    CAS  PubMed  Google Scholar 

  4. Panzica, G. C. et al. J. Neuroendocrinol. 24, 1–15 (2012).

    Article  CAS  Google Scholar 

  5. Zhu, D., Wang, M. D., Backstrom, T. & Wahlstrom, G. Br. J. Anaesth. 86, 403–412 (2001).

    Article  CAS  Google Scholar 

  6. Wu, Y. V. & Burnham, W. M. Seizure 63, 26–36 (2018).

    Article  Google Scholar 

  7. Powell, J. G., Garland, S., Preston, K. & Piszczatoski, C. Ann. Pharmacother. 54, 157–163 (2020).

    Article  CAS  Google Scholar 

  8. Osborne, L. M. et al. Psychoneuroendocrinology 79, 116–121 (2017).

    Article  CAS  Google Scholar 

  9. Wang, S. S., Kloth, A. D. & Badura, A. Neuron 83, 518–532 (2014).

    Article  CAS  Google Scholar 

  10. Liscovitch, N. & Chechik, G. PLoS Comput. Biol. 9, e1003185 (2013).

    Article  CAS  Google Scholar 

  11. Hampson, D. R. & Blatt, G. J. Front. Neurosci. 9, 420 (2015).

    Article  Google Scholar 

  12. D’Mello, A. M. & Stoodley, C. J. Front. Neurosci. 9, 408 (2015).

    PubMed  PubMed Central  Google Scholar 

  13. Stoodley, C. J. Front. Syst. Neurosci. 8, 92 (2014).

    Article  Google Scholar 

  14. Andreasen, N. C. & Pierson, R. Biol. Psychiatry 64, 81–88 (2008).

    Article  Google Scholar 

  15. Lai, M. C., Lombardo, M. V., Auyeung, B., Chakrabarti, B. & Baron-Cohen, S. J. Am. Acad. Child Adolesc. Psychiatry 54, 11–24 (2015).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Margaret M. McCarthy

  2. Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Margaret M. McCarthy

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  1. Margaret M. McCarthy
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Correspondence to Margaret M. McCarthy.

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McCarthy, M.M. Placental signaling influences cerebellum development. Nat Neurosci 24, 1343–1345 (2021). https://doi.org/10.1038/s41593-021-00918-1

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