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A visuomotor microcircuit in frontal cortex

Nature Neuroscience volume 24, pages 1345–1347 (2021)Cite this article

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Visually guided behavior begins with inputs to sensory cortices, but the decision to initiate actions engages the frontal cortex. A new study dissects a microcircuit for visual-to-motor transformation in the anterior cingulate cortex of the mouse with implications for impulsivity and disease states.

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Fig. 1: A visuomotor microcircuit.

References

  1. Zhang, S. et al. Science 345, 660–665 (2014).

    Article  CAS  Google Scholar 

  2. Leinweber, M., Ward, D. R., Sobczak, J. M., Attinger, A. & Keller, G. B. Neuron 95, 1420–1432 e1425 (2017).

    Article  CAS  Google Scholar 

  3. Schneider, D. M., Nelson, A. & Mooney, R. Nature 513, 189–194 (2014).

    Article  CAS  Google Scholar 

  4. Musall, S., Kaufman, M. T., Juavinett, A. L., Gluf, S. & Churchland, A. K. Nat. Neurosci. 22, 1677–1686 (2019).

    Article  CAS  Google Scholar 

  5. Mohajerani, M. H. et al. Nat. Neurosci. 16, 1426–1435 (2013).

    Article  CAS  Google Scholar 

  6. Kim, J. H., Ma, D. H., Jung, E., Choi, I. & Lee, S. H. Nat. Neurosci. https://doi.org/10.1038/s41593-021-00910-9 (2021).

  7. Barthas, F. & Kwan, A. C. Trends Neurosci. 40, 181–193 (2017).

    Article  CAS  Google Scholar 

  8. Duan, C. A. et al. Nat. Commun. 12, 2727 (2021).

    Article  CAS  Google Scholar 

  9. Huda, R. et al. Nat. Commun. 11, 6007 (2020).

    Article  CAS  Google Scholar 

  10. Li, B., Nguyen, T. P., Ma, C. & Dan, Y. Proc. Natl. Acad. Sci. USA 117, 17278–17287 (2020).

    Article  CAS  Google Scholar 

  11. Murakami, M., Vicente, M. I., Costa, G. M. & Mainen, Z. F. Nat. Neurosci. 17, 1574–1582 (2014).

    Article  CAS  Google Scholar 

  12. Siniscalchi, M. J., Phoumthipphavong, V., Ali, F., Lozano, M. & Kwan, A. C. Nat. Neurosci. 19, 1234–1242 (2016).

    Article  CAS  Google Scholar 

  13. Makino, H. et al. Neuron 94, 880–890 e888 (2017).

    Article  CAS  Google Scholar 

  14. Jentsch, J. D. & Taylor, J. R. Psychopharmacology (Berl.) 146, 373–390 (1999).

    Article  CAS  Google Scholar 

  15. Barthas, F. et al. Biol. Psychiatry 88, 541–553 (2020).

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by US National Institute of Mental Health grants R01 MH112750 and R21 MH118596 (A.C.K.), a Simons Foundation Autism Research Initiative Pilot Award (A.C.K.), a Gruber Science Fellowship (H.K.O.) and US National Institutes of Health training grant T32NS007224 (H.K.O.).

Author information

Authors and Affiliations

  1. Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, USA

    Heather K. Ortega

  2. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

    Alex C. Kwan

  3. Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA

    Alex C. Kwan

Authors
  1. Heather K. Ortega
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  2. Alex C. Kwan
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Correspondence to Alex C. Kwan.

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Ortega, H.K., Kwan, A.C. A visuomotor microcircuit in frontal cortex. Nat Neurosci 24, 1345–1347 (2021). https://doi.org/10.1038/s41593-021-00915-4

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