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NEURODEGENERATIVE DISEASE

Killing ageing neurons, one cell at a time

Nature Neuroscience volume 24, pages 759–760 (2021)Cite this article

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In neurodegenerative diseases, certain types of neurons perish first, but the mechanisms of this selective neuronal vulnerability remain unclear. A new study now highlights a crucial role for apolipoprotein E in driving neuronal death in both ageing and Alzheimer’s disease.

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Fig. 1: ApoE mediates selective neuronal vulnerability in Alzheimer’s disease.

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Authors and Affiliations

  1. German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany

    Jessica Wagner & Jonas J. Neher

  2. Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

    Jessica Wagner & Jonas J. Neher

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  1. Jessica Wagner
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  2. Jonas J. Neher
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Correspondence to Jonas J. Neher.

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The authors declare no competing interests.

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Wagner, J., Neher, J.J. Killing ageing neurons, one cell at a time. Nat Neurosci 24, 759–760 (2021). https://doi.org/10.1038/s41593-021-00855-z

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