Extended Data Fig. 2: Depressive-like behavioral tests in chronic stress mice. | Nature Neuroscience

Extended Data Fig. 2: Depressive-like behavioral tests in chronic stress mice.

From: Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states

Extended Data Fig. 2

a, An outline of the experimental procedure for mice with CRS treatment and behavioral tests. b-d, Behavioral tests in social interaction (b), tail-suspension (c), and forced-swim (d) in CRS mice when compared to control mice at 1 W, 2 W, 3 W, 4 W, 5 W, 6 W, 7 W. e, An outline of the experimental procedure for mice with CUS treatment and behavioral tests (Control 1W, n = 6 mice; CRS 1W, n = 11 mice; SI, P > 0.9999; TST, P > 0.9999; FST, P = 0.848; Control 2W, n = 6 mice; CRS 2W, n = 6 mice; SI, P > 0.9999; TST, P > 0.9999; FST, P > 0.9999; Control 3W, n = 6 mice; CRS 3W, n = 6 mice; SI, P < 0.001; TST, P = 0.034; FST, P = 0.040; Control 4W, n = 7 mice; CRS 4W, n = 9 mice; SI, P < 0.001; TST, P = 0.038; FST, P < 0.0001; Control 5W, n = 7 mice; CRS 5W, n = 7 mice; SI, P = 0.021; TST, P = 0.004; FST, P < 0.0001; Control 6W, n = 6 mice; CRS 6W, n = 11 mice; SI, P < 0.001; TST, P < 0.0001; FST, P = 0.004; Control 7W, n = 6 mice; CRS 7W, n = 6 mice; SI, P = 0.384; TST, P > 0.9999; FST, P > 0.9999). f-h, Behavioral tests in social interaction (f), tail-suspension (g), and forced-swim (h) upon CUS mice when compared to control mice at 4 D, 7 D, 10 D, 13 D, 15 D, 17 D, 24 D (Control 4D, n = 6 mice; CUS 4D, n = 8 mice; SI, P > 0.9999; TST, P > 0.9999; FST, P > 0.9999; Control 7D, n = 7 mice; CUS 7D, n = 9 mice; SI, P = 0.203; TST, P > 0.9999; FST, P > 0.9999; Control 10D, n = 6 mice; CUS 10D, n = 5 mice; SI, P = 0.009; TST, P = 0.044; FST, P = 0.043; Control 13D, n = 5 mice; CUS 13D, n = 6 mice; SI, P < 0.001; TST, P = 0.017; FST, P = 0.019; Control 15D, n = 5 mice; CUS 15D, n = 8 mice; SI, P = 0.019; TST, P = 0.037; FST, P =0.023; Control 17D, n = 6 mice; CUS 17D, n = 7 mice; SI, P < 0.001; TST, P = 0.045; FST, P = 0.021; Control 24D, n = 6 mice; CUS 24D, n = 8 mice; SI, P = 0.183; TST, P > 0.9999; FST, P = 0.437). Significance was assessed by one-way repeated measures ANOVA with post hoc comparison between groups in b, c, d, f and h. All data are presented as the mean ± s.e.m. * P < 0.05, ** P < 0.01, *** P < 0.001, n.s., not significant. For detailed statistics information, see Supplementary Table 1.

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