Extended Data Fig. 7: Bursting and regular rhythmic cholinergic neurons respond differently to hyperpolarization in vitro. | Nature Neuroscience

Extended Data Fig. 7: Bursting and regular rhythmic cholinergic neurons respond differently to hyperpolarization in vitro.

From: Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types

Extended Data Fig. 7

a, Peak latency statistics of auditory LFP average triggered on BF spikes in vivo (see Fig. 5b-c; red, n = 16 Burst-BFCN-SBs; orange, n = 12 Burst-BFCN-PLs; green, n = 9 Reg-BFCNs; *, p < 0.05; Burst-BFCN-SBs vs. Burst- BFCN-PLs, p = 0.546; Burst-BFCN-SBs vs. Reg-BFCNs, p = 0.014; Burst-BFCN-PLs vs. Reg-BFCNs, p = 0.017; two-sided Mann-Whitney U-test). Bars, median. b, Representative responses of a Burst-BFCN (top, red) and Reg-BFCN (bottom, green) upon short (20 ms) hyperpolarizing somatic current injection in vitro. Spike rasters of 30 consecutive current injection sessions are displayed below. c, Distribution of the first spike latencies following hyperpolarization. Individual cells (horizontal bar plots) are shown above summary histogram (red, n = 4 Burst-BFCNs, green, n = 6 Reg-BFCNs, p = 6.47 × 10-44, two-sided Mann-Whitney U-test; box plots show median, interquartile range and non-outlier range).

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