Extended Data Fig. 3: Many regular rhythmic basal forebrain neurons are cholinergic. | Nature Neuroscience

Extended Data Fig. 3: Many regular rhythmic basal forebrain neurons are cholinergic.

From: Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types

Extended Data Fig. 3

a-c, Auto-correlations of untagged bursting (a), Poisson-like (b), and regular rhythmic (c) NB neurons. d, Average auto-correlations (red, n = 559 untagged strongly bursting; orange, n = 692 Poisson-like; green, n = 17 regular rhythmic basal forebrain neurons). Solid lines, mean; shading, s.e.m. e, Scatter plot showing burst index and refractory period of the same neurons. f, Pearson’s correlation between refractory period and theta index (p = 6.36 × 10-6 for n = 17 regular rhythmic basal forebrain neurons (green), one-sided F-test, F(1,15) = 45.77; red, n = 559 untagged strongly bursting; orange, n = 692 Poisson-like basal forebrain neurons). g, Median theta index (red, n = 559 untagged strongly bursting; orange, n = 692 Poisson-like; green, n = 17 regular rhythmic basal forebrain neurons; ***, p < 0.001; strongly bursting vs. Poisson-like, p = 1.99 × 10-24; strongly bursting vs. regular rhythmic, p = 4.41 × 10-8; Poisson-like vs. regular rhythmic, 6.04 × 10-11; two-sided Mann-Whitney U-test). Bars, median. h, Predictive value of regular rhythmic firing pattern for cholinergic identity as a function of relative refractory period. Black line and right y-axis correspond to the ratio of (identified or putative) cholinergic neurons to all neurons in the bin.

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