Extended Data Fig. 4: Effects of cue duplication on CA1 place fields with random reward delivery. | Nature Neuroscience

Extended Data Fig. 4: Effects of cue duplication on CA1 place fields with random reward delivery.

From: Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus

Extended Data Fig. 4

a, An example cell with the duplication of cue A during recording. b, Ramp depolarization, theta amplitude and spiking rate before (black) and after (red) the cue duplication in the example cell shown in (a). ce, Position-variant ramp depolarization (c), theta amplitude (d) and spiking rate (e) before (black) and after (red) the cue duplication (n = 12 cells from 7 animals). Solid curves and shaded areas depict mean±s.e.m. Through (b) to (e), locations of cue A and D were marked with light blue and yellow shadings, respectively, as in Fig. 1. fh, Statistical comparisons of peak ramp depolarization (f), theta amplitude (g) and spiking rate (h) following the cue duplication. Peak values of each metric were calculated within location 1 (between the two light blue lines in (c)-(e); grey for control, pink for cue duplication) and location 4 (between the two yellow lines in (c)-(e); black for control, red for cue duplication). Ramp depolarization (f): P = 1.485e-7 for control, loc. 1 vs. loc. 4; P = 0.0027 for duplication, loc. 1 vs. loc. 4; P = 0.9783 for control loc. 1 vs. duplication loc. 1; P = 0.001 for control loc. 4 vs. duplication loc. 4. Theta amplitude (g): P = 1.029e-5 for control, loc. 1 vs. loc. 4; P = 0.0061 for duplication, loc. 1 vs. loc. 4; P = 0.7968 for control loc. 1 vs. duplication loc. 1; P = 0.0116 for control loc. 4 vs. duplication loc. 4. Spiking rate (h): P = 8.163e-7 for control, loc. 1 vs. loc. 4; P = 0.0024 for duplication, loc. 1 vs. loc. 4; P = 0.1988 for control loc. 1 vs. duplication loc. 1; P = 0.0083 for control loc. 4 vs. duplication loc. 4 (n = 12 cells from 7 animals). Solid curves and shaded areas depict mean±s.e.m. Bar graphs and error bars represent mean and s.e.m., respectively. Paired student t-test (2-sided) was conducted in all analyses. *: P < 0.05, **: P < 0.01, ***: P < 0.001, N.S.: not significant (P > = 0.05).

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