Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Myelin makes memories

Three new studies show that activity-dependent formation of myelin contributes to memory consolidation and recall, possibly by increasing functional coupling between neuronal ensembles encoding experience.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Consolidation and/or recall of fear memory requires new myelin formation.


  1. Fields, R. D. Nat. Rev. Neurosci. 16, 756–767 (2015).

    Article  CAS  Google Scholar 

  2. Dutta, D. J. et al. Proc. Natl Acad. Sci. USA 115, 11832–11837 (2018).

    Article  CAS  Google Scholar 

  3. Zatorre, R. J., Fields, R. D. & Johansen-Berg, H. Nat. Neurosci. 15, 528–536 (2012).

    Article  CAS  Google Scholar 

  4. Pajevic, S., Basser, P. J. & Fields, R. D. Neuroscience 276, 135–147 (2014).

    Article  CAS  Google Scholar 

  5. Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R. & Kheirbek, M. A. Nat. Neurosci. (2020).

  6. McKenzie, I. A. et al. Science 346, 318–322 (2014).

    Article  CAS  Google Scholar 

  7. Steadman, P. E. et al. Neuron 105, 150–164.e6 (2020).

    Article  CAS  Google Scholar 

  8. Bartzokis, G. et al. Neurobiol. Aging 25, 843–851 (2004).

    Article  CAS  Google Scholar 

  9. Wang, F. et al. Nat. Neurosci. (2020).

  10. Nave, K. A. Nat. Rev. Neurosci. 11, 275–283 (2010).

    Article  CAS  Google Scholar 

  11. Kato, D. et al. Glia 68, 193–210 (2020).

    Article  Google Scholar 

  12. Xiao, L. et al. Nat. Neurosci. 19, 1210–1217 (2016).

    Article  CAS  Google Scholar 

  13. Wake, H., Lee, P. R. & Fields, R. D. Science 333, 1647–1651 (2011).

    Article  CAS  Google Scholar 

  14. Bergles, D. E., Roberts, J. D., Somogyi, P. & Jahr, C. E. Nature 405, 187–191 (2000).

    Article  CAS  Google Scholar 

  15. Sakry, D. et al. PLoS Biol. 12, e1001993 (2014).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to R. Douglas Fields.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fields, R.D., Bukalo, O. Myelin makes memories. Nat Neurosci 23, 469–470 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing