Postmortem studies have previously suggested that adult olfactory neurogenesis occurs in humans. In new research, Durante and colleagues obtained fresh tissue from healthy adult humans via endoscopic nasal surgery and used single-cell RNA sequencing (RNA-seq) to identify the entire neurogenic trajectory in the olfactory epithelium, confirming the existence of human olfactory neurogenesis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sorrells, S. F. et al. Nature 555, 377–381 (2018).
Boldrini, M. et al. Cell Stem Cell 22, 589–599.e5 (2018).
Kempermann, G. et al. Cell Stem Cell 23, 25–30 (2018).
Durante, M. A. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-020-0587-9 (2020).
Lim, D. A. & Alvarez-Buylla, A. Cold Spring Harb. Perspect. Biol. 8, a018820 (2016).
Brann, J. H. & Firestein, S. J. Front. Neurosci. https://doi.org/10.3389/fnins.2014.00182 (2014).
Fletcher, R. B. et al. Cell Stem Cell 20, 817–830.e8 (2017).
Olender, T. et al. BMC Genomics 17, 619 (2016).
Chess, A., Simon, I., Cedar, H. & Axel, R. Cell 78, 823–834 (1994).
Hahn, C.-G. et al. J. Comp. Neurol. 483, 154–163 (2005).
Holbrook, E. H., Wu, E., Curry, W. T., Lin, D. T. & Schwob, J. E. Laryngoscope 121, 1687–1701 (2011).
Bergmann, O. et al. Neuron 74, 634–639 (2012).
Chen, M., Reed, R. R. & Lane, A. P. Cell Stem Cell 25, 501–513.e5 (2019).
Alves, J., Petrosyan, A. & Magalhães, R. World J. Clin. Cases 2, 661–667 (2014).
Scopa, C. et al. Cell Death Differ. https://doi.org/10.1038/s41418-019-0409-3 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Berger, T., Lee, H. & Thuret, S. Neurogenesis right under your nose. Nat Neurosci 23, 297–298 (2020). https://doi.org/10.1038/s41593-020-0596-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-020-0596-8
This article is cited by
-
Olfactory Dysfunction in Traumatic Brain Injury: the Role of Neurogenesis
Current Allergy and Asthma Reports (2020)