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NEUROINFLAMMATION

Inflammation drives fibrotic scars in the CNS

Nature Neuroscience volume 24, pages 157–159 (2021)Cite this article

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Fibrotic scarring after inflammation is well-characterized in peripheral tissues, but its role in the CNS is less clear. A new study shows that local proliferation of CNS fibroblasts drives fibrotic scar formation in response to circulating inflammatory cell infiltration in a model of multiple sclerosis, which may limit repair.

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Fig. 1: Ablation of proliferating CNS fibroblasts during EAE attenuates collagen fibrosis and facilitates OPC repopulation of inflamed neural parenchyma.

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  1. Department of Neurobiology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA

    Michael V. Sofroniew

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  1. Michael V. Sofroniew
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Correspondence to Michael V. Sofroniew.

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Sofroniew, M.V. Inflammation drives fibrotic scars in the CNS. Nat Neurosci 24, 157–159 (2021). https://doi.org/10.1038/s41593-020-00777-2

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