A new study proposes an exciting new model of neuronal diversification in the developing enteric nervous system (ENS) and establishes a detailed molecular taxonomy for enteric neurons. Their findings open new horizons for ENS research and for developing cell-based therapies for ENS disorders.
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References
Furness, J.B. The Enteric Nervous System (Blackwell Publishing, 2006).
Ganz, J., Melancon, E. & Eisen, J. S. Methods Cell Biol. 134, 139–164 (2016).
Neunlist, M. et al. Nat. Rev. Gastroenterol. Hepatol. 10, 90–100 (2013).
Ganz, J. Dev. Dyn. 247, 268–278 (2018).
Rao, M. & Gershon, M. D. Nat. Rev. Neurosci. 19, 552–565 (2018).
Morarach, K. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-020-00736-x (2020).
Zeisel, A. et al. Cell 174, 999–1014.e22 (2018).
Holguera, I. & Desplan, C. Science 362, 176–180 (2018).
Lasrado, R. et al. Science 356, 722–726 (2017).
Drokhlyansky, E. et al. Cell 182, 1606–1622.e23 (2020).
May-Zhang, A.A. et al. Gastroenterology https://doi.org/10.1053/j.gastro.2020.09.032 (2020).
Brosens, E. et al. Dev. Biol. 417, 198–208 (2016).
Heuckeroth, R. O. Nat. Rev. Gastroenterol. Hepatol. 15, 152–167 (2018).
Rao, M. & Gershon, M. D. Nat. Rev. Gastroenterol. Hepatol. 13, 517–528 (2016).
Burns, A. J. et al. Dev. Biol. 417, 229–251 (2016).
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Ganz, J. Revealing the complexity of the gut’s brain. Nat Neurosci 24, 1–2 (2021). https://doi.org/10.1038/s41593-020-00769-2
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DOI: https://doi.org/10.1038/s41593-020-00769-2