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Diversity and dynamism in the cerebellum

Nature Neuroscience volume 24, pages 160–167 (2021)Cite this article

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A Publisher Correction to this article was published on 04 January 2021

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Abstract

The past several years have brought revelations and paradigm shifts in research on the cerebellum. Historically viewed as a simple sensorimotor controller with homogeneous architecture, the cerebellum is increasingly implicated in cognitive functions. It possesses an impressive diversity of molecular, cellular and circuit mechanisms, embedded in a dynamic, recurrent circuit architecture. Recent insights about the diversity and dynamism of the cerebellum provide a roadmap for the next decade of cerebellar research, challenging some old concepts, reinvigorating others and defining major new research directions.

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Fig. 1: Intricacies of the cerebellar circuit.
Fig. 2: Revision of canonical ideas about inputs to the cerebellum via mossy fiber and climbing fiber pathways, based on recent discoveries.
Fig. 3: A potential solution for learned timing: a temporal basis set plus highly selective and specialized temporal contingencies for plasticity.
Fig. 4: Possible transfer of learning from early acquisition in the cerebellar cortex to consolidation in the cerebellar nucleus.

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Authors and Affiliations

  1. Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

    Chris I. De Zeeuw

  2. Netherlands Institute for Neuroscience, Royal Academy of Sciences (KNAW), Amsterdam, The Netherlands

    Chris I. De Zeeuw

  3. Department of Neurobiology, Duke University, Durham, NC, USA

    Stephen G. Lisberger

  4. Department of Neurobiology, Stanford University, Stanford, CA, USA

    Jennifer L. Raymond

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  1. Chris I. De Zeeuw
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  2. Stephen G. Lisberger
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C.I.D.Z., S.G.L. and J.L.R. contributed equally to the conceptualization and writing.

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Correspondence to Stephen G. Lisberger.

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De Zeeuw, C.I., Lisberger, S.G. & Raymond, J.L. Diversity and dynamism in the cerebellum. Nat Neurosci 24, 160–167 (2021). https://doi.org/10.1038/s41593-020-00754-9

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