Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


An ‘edgy’ new look

Network neuroscientists envision the brain as a network of nodes (regions) linked via edges (connections). A long-held assumption is that node-centric interactions are the primary phenomena of interest. Faskowitz et al. introduce a novel edge-centric framework with the potential to usher in a new era of discovery in connectomics research.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: New metrics for network neuroscience.


  1. Fornito, A., Zalesky, A. & Breakspear, M. Neuroimage 80, 426–444 (2013).

    Article  Google Scholar 

  2. Bassett, D. S. & Sporns, O. Nat. Neurosci. 20, 353–364 (2017).

    Article  CAS  Google Scholar 

  3. Rubinov, M. & Sporns, O. Neuroimage 52, 1059–1069 (2010).

    Article  Google Scholar 

  4. Faskowitz, J., Esfahlani, F.Z., Jo, Y., Sporns, O., Betzel, R.F. Nat. Neurosci. (2020).

  5. Van Essen, D. C. et al. Neuroimage 80, 62–79 (2013).

    Article  Google Scholar 

  6. Gordon, E. M. et al. Neuron 95, 791–807.e7 (2017).

    Article  CAS  Google Scholar 

  7. O’Connor, D. et al. Gigascience 6, 1–14 (2017).

    Article  Google Scholar 

  8. Pessoa, L. Phys. Life Rev. 11, 400–435 (2014).

    Article  Google Scholar 

  9. McIntosh, A. R. Neuroinformatics 2, 175–182 (2004).

    Article  Google Scholar 

  10. Mesulam, M. M. Ann. Neurol. 28, 597–613 (1990).

    Article  CAS  Google Scholar 

  11. Calhoun, V. D., Miller, R., Pearlson, G. & Adalı, T. Neuron 84, 262–274 (2014).

    Article  CAS  Google Scholar 

  12. Uddin, L. Q., Yeo, B. T. T. & Spreng, R. N. Brain Topogr. 32, 926–942 (2019).

    Article  Google Scholar 

  13. Uddin, L. Q. Nat. Rev. Neurosci. 16, 55–61 (2015).

    Article  CAS  Google Scholar 

  14. Saggar, M. & Uddin, L.Q. eNeuro (2019).

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Lucina Q. Uddin.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Uddin, L.Q. An ‘edgy’ new look. Nat Neurosci 23, 1471–1472 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing