Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NEURODEGENERATIVE DISEASE

Help from peripheral macrophages in ALS?

Nature Neuroscience volume 23, pages 1311–1312 (2020)Cite this article

Subjects

Chiot and colleagues investigated whether peripheral macrophages play a role in amyotrophic lateral sclerosis (ALS) pathology, finding that macrophages along peripheral motor neuron axons react to neurodegeneration. Modifying reactive oxygen species (ROS) signaling in peripheral macrophages, using bone marrow cell replacement, reduces both macrophage and microglia inflammatory response, delays pathology and increases survival in ALS mouse models.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Genetic modulation of peripheral macrophages has profound impacts on CNS microglia in the spinal cord.

References

  1. Boillée, S. et al. Science 312, 1389–1392 (2006).

    Article  Google Scholar 

  2. Clement, A. M. et al. Science 302, 113–117 (2003).

    Article  CAS  Google Scholar 

  3. Chiot, A. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-020-00718-z (2020).

  4. Corti, S. et al. Brain 127, 2518–2532 (2004).

    Article  Google Scholar 

  5. Solomon, J. N. et al. Glia 53, 744–753 (2006).

    Article  Google Scholar 

  6. Butovsky, O. et al. J. Clin. Invest. 122, 3063–3087 (2012).

    Article  CAS  Google Scholar 

  7. Bennett, M. L. et al. Proc. Natl. Acad. Sci. USA 113, E1738–E1746 (2016).

    Article  CAS  Google Scholar 

  8. Marden, J. J. et al. J. Clin. Invest. 117, 2913–2919 (2007).

    Article  CAS  Google Scholar 

  9. Wu, D. C., Ré, D. B., Nagai, M., Ischiropoulos, H. & Przedborski, S. Proc. Natl. Acad. Sci. USA 103, 12132–12137 (2006).

    Article  CAS  Google Scholar 

  10. Jara, J. H. et al. J. Neuroinflammation 16, 196 (2019).

    Article  Google Scholar 

  11. Engelhardt, J. I. & Appel, S. H. Arch. Neurol. 47, 1210–1216 (1990).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

I thank B. Genc for preparing the figure.

Author information

Authors and Affiliations

  1. Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    P. Hande Özdinler

Authors
  1. P. Hande Özdinler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. Hande Özdinler.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Özdinler, P.H. Help from peripheral macrophages in ALS?. Nat Neurosci 23, 1311–1312 (2020). https://doi.org/10.1038/s41593-020-00727-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-020-00727-y

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing