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BRAIN ORGANIZATION

Functional boundaries within human subcortex

Abrupt spatial changes in anatomic and functional properties of the brain demarcate boundaries between discrete functional areas. While previous work has identified these boundaries in cortex, a new study by Tian et al. applies this approach for the first time to subcortical structures within the in vivo human brain.

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Fig. 1: The gradientography method traces paths of changing connectivity through the human subcortex.

References

  1. Sejnowski, T.J. & Churchland, P.S. Brain and cognition. in Foundations of Cognitive Science (ed. Posner, M. I.) 888 (MIT Press, 1989).

  2. Brodmann, K. Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues (Barth, 1909).

  3. Felleman, D. J. & Van Essen, D. C. Cereb. Cortex 1, 1–47 (1991).

    Article  CAS  Google Scholar 

  4. Wig, G. S., Laumann, T. O. & Petersen, S. E. Neuroimage 93, 276–291 (2014).

    Article  Google Scholar 

  5. Gordon, E. M. et al. Cereb. Cortex 26, 288–303 (2016).

    Article  Google Scholar 

  6. Glasser, M. F. et al. Nature 536, 171–178 (2016).

    Article  CAS  Google Scholar 

  7. Schaefer, A. et al. Cereb. Cortex 28, 3095–3114 (2018).

    Article  Google Scholar 

  8. Ji, J. L. et al. Neuroimage 185, 35–57 (2019).

    Article  Google Scholar 

  9. Seitzman, B. A. et al. Neuroimage 206, 116290 (2019).

    Article  Google Scholar 

  10. Haber, S. N. J. Chem. Neuroanat. 26, 317–330 (2003).

    Article  Google Scholar 

  11. Tian, Y., Margulies, D.S., Breakspear, M. & Zalesky, A. Nat. Neurosci. https://doi.org/s41593-020-00711-6 (2020).

  12. Gordon, E. M. et al. Neuron 95, 791–807.e7 (2017).

    Article  CAS  Google Scholar 

  13. Salehi, M. et al. Neuroimage 208, 116366 (2020).

    Article  Google Scholar 

Download references

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Correspondence to Evan M. Gordon.

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Gordon, E.M. Functional boundaries within human subcortex. Nat Neurosci 23, 1312–1314 (2020). https://doi.org/10.1038/s41593-020-00721-4

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