A new study shows that, immediately after axon injury, glycolysis is increased in Schwann cells to provide axons with energy and prevent them from degenerating. The authors also identify possible therapeutic targets that could be modulated to promote axonal protection.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits
Cell Death & Disease Open Access 07 March 2024
-
Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells
Cell Communication and Signaling Open Access 01 February 2024
-
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
Acta Neuropathologica Communications Open Access 25 February 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
12 November 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
References
He, Z. & Jin, Y. Neuron 90, 437–451 (2016).
Mahar, M. & Cavalli, V. Nat. Rev. Neurosci. 19, 323–337 (2018).
Jessen, K. R. & Mirsky, R. J. Physiol. (Lond.) 594, 3521–3531 (2016).
Fünfschilling, U. et al. Nature 485, 517–521 (2012).
Lee, Y. et al. Nature 487, 443–448 (2012).
Babetto, E., Wong, K.M. & Beirowski, B. Nature Neurosci. https://doi.org/10.1038/s41593-020-0689-4 (2020).
Koley, S., Rozenbaum, M., Fainzilber, M. & Terenzio, M. Neurosci. Res. 139, 26–36 (2019).
Arthur-Farraj, P. J. et al. Neuron 75, 633–647 (2012).
Terenzio, M. et al. Science 359, 1416–1421 (2018).
Atanasoski, S. et al. J. Neurosci. 26, 2124–2131 (2006).
Guertin, A. D., Zhang, D. P., Mak, K. S., Alberta, J. A. & Kim, H. A. J. Neurosci. 25, 3478–3487 (2005).
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G. & Thompson, C. B. Cell Metab. 7, 11–20 (2008).
Figlia, G., Norrmen, C., Pereira, J. A., Gerber, D. & Suter, U. eLife 6, e29241 (2017).
Figlia, G., Gerber, D. & Suter, U. Glia 66, 693–707 (2018).
Norrmén, C. et al. J. Neurosci. 38, 4811–4828 (2018).
Saab, A. S. & Nave, K. A. Curr. Opin. Neurobiol. 47, 104–112 (2017).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Trimarco, A., Taveggia, C. Schwann cell energy to die for. Nat Neurosci 23, 1179–1181 (2020). https://doi.org/10.1038/s41593-020-00707-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-020-00707-2
This article is cited by
-
Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells
Cell Communication and Signaling (2024)
-
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits
Cell Death & Disease (2024)
-
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
Acta Neuropathologica Communications (2021)
