A new study shows that, immediately after axon injury, glycolysis is increased in Schwann cells to provide axons with energy and prevent them from degenerating. The authors also identify possible therapeutic targets that could be modulated to promote axonal protection.
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Change history
12 November 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
References
He, Z. & Jin, Y. Neuron 90, 437–451 (2016).
Mahar, M. & Cavalli, V. Nat. Rev. Neurosci. 19, 323–337 (2018).
Jessen, K. R. & Mirsky, R. J. Physiol. (Lond.) 594, 3521–3531 (2016).
Fünfschilling, U. et al. Nature 485, 517–521 (2012).
Lee, Y. et al. Nature 487, 443–448 (2012).
Babetto, E., Wong, K.M. & Beirowski, B. Nature Neurosci. https://doi.org/10.1038/s41593-020-0689-4 (2020).
Koley, S., Rozenbaum, M., Fainzilber, M. & Terenzio, M. Neurosci. Res. 139, 26–36 (2019).
Arthur-Farraj, P. J. et al. Neuron 75, 633–647 (2012).
Terenzio, M. et al. Science 359, 1416–1421 (2018).
Atanasoski, S. et al. J. Neurosci. 26, 2124–2131 (2006).
Guertin, A. D., Zhang, D. P., Mak, K. S., Alberta, J. A. & Kim, H. A. J. Neurosci. 25, 3478–3487 (2005).
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G. & Thompson, C. B. Cell Metab. 7, 11–20 (2008).
Figlia, G., Norrmen, C., Pereira, J. A., Gerber, D. & Suter, U. eLife 6, e29241 (2017).
Figlia, G., Gerber, D. & Suter, U. Glia 66, 693–707 (2018).
Norrmén, C. et al. J. Neurosci. 38, 4811–4828 (2018).
Saab, A. S. & Nave, K. A. Curr. Opin. Neurobiol. 47, 104–112 (2017).
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Trimarco, A., Taveggia, C. Schwann cell energy to die for. Nat Neurosci 23, 1179–1181 (2020). https://doi.org/10.1038/s41593-020-00707-2
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DOI: https://doi.org/10.1038/s41593-020-00707-2
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