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MITOCHONDRIA

Dopamine fuels its own release

Nature Neuroscience volume 23, pages 1–2 (2020)Cite this article

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A new study shows that the enzyme monoamine oxidase funnels a byproduct of dopamine metabolism, H2O2, directly into the mitochondrial electron transport chain, stimulating ATP production. This alternative energy pathway may protect dopaminergic neurons from the toxicity induced by dopamine metabolism while supporting phasic firing.

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Fig. 1: Alternative bioenergetic pathway used for ATP production during dopamine metabolism.

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Authors and Affiliations

  1. Department of Internal Medicine (Endocrinology), Yale University School of Medicine, New Haven, CT, USA

    Rongmin Chen & Elizabeth A. Jonas

  2. Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA

    Elizabeth A. Jonas

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  1. Rongmin Chen
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  2. Elizabeth A. Jonas
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Correspondence to Elizabeth A. Jonas.

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The authors declare no competing interests.

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Chen, R., Jonas, E.A. Dopamine fuels its own release. Nat Neurosci 23, 1–2 (2020). https://doi.org/10.1038/s41593-019-0563-4

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