MITOCHONDRIA

Dopamine fuels its own release

A new study shows that the enzyme monoamine oxidase funnels a byproduct of dopamine metabolism, H2O2, directly into the mitochondrial electron transport chain, stimulating ATP production. This alternative energy pathway may protect dopaminergic neurons from the toxicity induced by dopamine metabolism while supporting phasic firing.

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Fig. 1: Alternative bioenergetic pathway used for ATP production during dopamine metabolism.

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Correspondence to Elizabeth A. Jonas.

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Chen, R., Jonas, E.A. Dopamine fuels its own release. Nat Neurosci 23, 1–2 (2020). https://doi.org/10.1038/s41593-019-0563-4

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