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Norepinephrine as a modulator of microglial dynamics

Two new studies demonstrate the importance of awake imaging to investigate microglia–neuron interactions. These studies show that microglial dynamics are influenced by neuronal activity, and they provide evidence that norepinergic signaling plays an important role in this effect.

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Fig. 1: Schematic illustration of changes of microglial dynamics in awake and anesthetized mice.


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This work was supported by SFB 1089‚ Synaptic Micronetworks in Health and Disease. Thanks to R. McManus for proofreading the article.

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Correspondence to Michael T. Heneka.

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The authors declare no competing interests.

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Mercan, D., Heneka, M.T. Norepinephrine as a modulator of microglial dynamics. Nat Neurosci 22, 1745–1746 (2019).

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