Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus to the lateral habenula via the central amygdala is now uncovered as a key neural circuit governing comorbid depressive symptoms in chronic pain.
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Acknowledgements
The authors acknowledge funding from the Deutsche Forschungsgemeinschaft in form of grants in Collaborative Research Center 1158 to R.K. (projects B01 and B06) and to A.T.T. (project S01).
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Tappe-Theodor, A., Kuner, R. A common ground for pain and depression. Nat Neurosci 22, 1612–1614 (2019). https://doi.org/10.1038/s41593-019-0499-8
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DOI: https://doi.org/10.1038/s41593-019-0499-8
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