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RAN translation down

Repeat-associated non-AUG (RAN) translation generates toxic repeat proteins from pathological repeat expansions found in certain neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. How to suppress RAN translation has so far been unknown. A new study now reports a selective regulator of RAN translation identified in a genetic screen in yeast.

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Fig. 1: RPS25 depletion specifically suppresses RAN translation, but not global translation, in yeast and human cells and ameliorates C9orf72-linked neurodegeneration in Drosophila and induced pluripotent stem cell (iPSC)-derived motor neurons.


  1. DeJesus-Hernandez, M. et al. Neuron 72, 245–256 (2011).

    Article  CAS  Google Scholar 

  2. Renton, A. E. et al. Neuron 72, 257–268 (2011).

    Article  CAS  Google Scholar 

  3. Gitler, A. D. & Tsuiji, H. Brain Res. 1647, 19–29 (2016).

    Article  CAS  Google Scholar 

  4. Gijselinck, I. et al. Lancet Neurol. 11, 54–65 (2012).

    Article  CAS  Google Scholar 

  5. Lee, Y. B. et al. Cell Rep. 5, 1178–1186 (2013).

    Article  CAS  Google Scholar 

  6. Ash, P. E. et al. Neuron 77, 639–646 (2013).

    Article  CAS  Google Scholar 

  7. Mori, K. et al. Science 339, 1335–1338 (2013).

    Article  CAS  Google Scholar 

  8. Balendra, R. & Isaacs, A. M. Nat. Rev. Neurol. 14, 544–558 (2018).

    Article  CAS  Google Scholar 

  9. Yamada, S.B. et al. Nat. Neurosci. (2019).

  10. Hertz, M. I., Landry, D. M., Willis, A. E., Luo, G. & Thompson, S. R. Mol. Cell. Biol. 33, 1016–1026 (2013).

    Article  CAS  Google Scholar 

  11. Mizielinska, S. et al. Science 345, 1192–1194 (2014).

    Article  CAS  Google Scholar 

  12. May, S. et al. Acta Neuropathol. 128, 485–503 (2014).

    Article  CAS  Google Scholar 

  13. Bañez-Coronel, M. et al. Neuron 88, 667–677 (2015).

    Article  Google Scholar 

  14. Scoles, D. R. et al. PLoS One 10, e0128769 (2015).

    Article  Google Scholar 

  15. Armache, J. P. et al. Proc. Natl Acad. Sci. USA 107, 19754–19759 (2010).

    Article  CAS  Google Scholar 

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Correspondence to Dorothee Dormann.

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Hutten, S., Dormann, D. RAN translation down. Nat Neurosci 22, 1379–1380 (2019).

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