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NEURODEGENERATION

RAN translation down

Nature Neuroscience volume 22, pages 1379–1380 (2019)Cite this article

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Repeat-associated non-AUG (RAN) translation generates toxic repeat proteins from pathological repeat expansions found in certain neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. How to suppress RAN translation has so far been unknown. A new study now reports a selective regulator of RAN translation identified in a genetic screen in yeast.

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Fig. 1: RPS25 depletion specifically suppresses RAN translation, but not global translation, in yeast and human cells and ameliorates C9orf72-linked neurodegeneration in Drosophila and induced pluripotent stem cell (iPSC)-derived motor neurons.

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Authors and Affiliations

  1. BioMedical Center (BMC), Cell Biology, Ludwig-Maximilians-Universität München, Munich, Germany

    Saskia Hutten & Dorothee Dormann

  2. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

    Dorothee Dormann

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  1. Saskia Hutten
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  2. Dorothee Dormann
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Correspondence to Dorothee Dormann.

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Hutten, S., Dormann, D. RAN translation down. Nat Neurosci 22, 1379–1380 (2019). https://doi.org/10.1038/s41593-019-0482-4

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