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Connectomics of neurodegeneration

Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.

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Fig. 1: Network modeling of neurodegeneration.


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Correspondence to Ellen Kuhl.

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Kuhl, E. Connectomics of neurodegeneration. Nat Neurosci 22, 1200–1202 (2019).

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