CEREBROVASCULATURE

Sharpening the tools for pericyte research

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The creation of a murine Cre driver specific to CNS capillary pericytes has opened a major bottleneck in brain microvascular research. Using this tool, pericyte loss in the adult brain is shown to induce neuronal loss due to concurrent microcirculatory failure and depletion of the protective trophic factor pleiotrophin.

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Fig. 1: Selective ablation of capillary pericytes in the adult brain leads to concurrent microcirculatory failure and depletion of pleiotrophin levels.

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Correspondence to Andy Y. Shih.

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Berthiaume, A., Shih, A.Y. Sharpening the tools for pericyte research. Nat Neurosci 22, 1041–1043 (2019) doi:10.1038/s41593-019-0437-9

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