NEURODEGENERATION

A traffic jam leads to Lewy bodies

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Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

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Fig. 1: Different models of αSyn dysfunction in disease.

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Correspondence to Tim Bartels.

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