Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


A traffic jam leads to Lewy bodies

Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Different models of αSyn dysfunction in disease.


  1. Spillantini, M. G. et al. Nature 388, 839–840 (1997).

    Article  CAS  Google Scholar 

  2. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M. & Goedert, M. Proc. Natl. Acad. Sci. USA 95, 6469–6473 (1998).

    Article  CAS  Google Scholar 

  3. Shahmoradian, S.H. et al. Nat. Neurosci. (2019).

  4. Braak, H. et al. Neurobiol. Aging 24, 197–211 (2003).

    Article  Google Scholar 

  5. Fortin, D. L., Nemani, V. M., Nakamura, K. & Edwards, R. H. Mov. Disord. 25 Suppl 1, S21–S26 (2010).

    Article  Google Scholar 

  6. Davidson, W. S., Jonas, A., Clayton, D. F. & George, J. M. J. Biol. Chem. 273, 9443–9449 (1998).

    Article  CAS  Google Scholar 

  7. Sidransky, E., Samaddar, T. & Tayebi, N. Neurology 73, 1424–1425; author reply 1425–1426 (2009).

  8. Fanning, S. et al. Mol. Cell 73, 1001–1014.e8 (2019).

    Article  CAS  Google Scholar 

  9. Wang, L. et al. Curr. Biol. 24, 2319–2326 (2014).

    Article  CAS  Google Scholar 

  10. Cooper, A. A. et al. Science 313, 324–328 (2006).

    Article  CAS  Google Scholar 

  11. Dettmer, U. et al. Hum. Mol. Genet. 26, 3466–3481 (2017).

    Article  CAS  Google Scholar 

  12. Galvagnion, C. et al. Nat. Chem. Biol. 11, 229–234 (2015).

    Article  CAS  Google Scholar 

  13. Rovere, M., Sanderson, J. B., Fonseca-Ornelas, L., Patel, D. S. & Bartels, T. FEBS Lett. 592, 1464–1472 (2018).

    Article  CAS  Google Scholar 

  14. Kim, S. et al. Proc. Natl. Acad. Sci. USA 115, 798–803 (2018).

    Article  CAS  Google Scholar 

  15. Nuber, S. et al. Neuron 100, 75–90.e5 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Tim Bartels.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bartels, T. A traffic jam leads to Lewy bodies. Nat Neurosci 22, 1043–1045 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing