Supplementary Figure 3: Computer model of how changes in light power, duty cycle, and pulse duration affect temperature. | Nature Neuroscience

Supplementary Figure 3: Computer model of how changes in light power, duty cycle, and pulse duration affect temperature.

From: Thermal constraints on in vivo optogenetic manipulations

Supplementary Figure 3

. A, Simulation of light delivery at varying powers using a published computer model1. Temperature measurements predicted at 1 mm from the tip of a 200 μm optical fiber with 532 nm light delivered for a 1 sec continuous pulse. B, Simulation of light delivery with varying duty cycle at 15 mW. Other parameters equivalent to Panel A. C, Simulation of light delivery with varying pulse duration at 15 mW. Other parameters equivalent to Panel A. Note near equivalence of temperature responses in each case as the amount of light is changed by altering the power (Panel A), duty cycle (Panel B), or pulse duration (Panel C).

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