Supplementary Figure 7: Working model. | Nature Neuroscience

Supplementary Figure 7: Working model.

From: Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes

Supplementary Figure 7

Ascl1 and Neurog2 bind to their preferred sites in the genome mediated intrinsically by their bHLH DNA-binding domain. This divergent binding, in return, results in distinct chromatin landscapes that affect the activity of downstream TFs in establishing generic and neuron-specific phenotypes (TF, transcription factor).

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