Supplementary Figure 4: The k-mer preference and the expression profile of the A[N]bHLH chimera. | Nature Neuroscience

Supplementary Figure 4: The k-mer preference and the expression profile of the A[N]bHLH chimera.

From: Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes

Supplementary Figure 4

a, The A[N]bHLH chimera binding sites are enriched in Neurog2-preferred core and flanking k-mers. b, Volcano plot comparing the gene expression between iA and iA[N]bHLH at 48 h after induction by RNA-seq. Colored dots represent differentially expressed genes in iA (blue) or iA[N]bHLH(pink) (q-value cut-off < 0.01, Wald test) (iA 48 h n = 5; iA[N]bHLH 48 h n = 2 independent cell differentiations). c, Volcano plot comparing the gene expression between iN and iA[N]bHLH at 48 h after induction by RNA-seq. Colored dots represent differentially expressed genes in iN (green) or iA[N]bHLH(pink) (q-value cut-off < 0.01, Wald test) (iA[N]bHLH 48 h n = 2; iN 48 h n = 2 independent cell differentiations).

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