Supplementary Figure 3: Nucleotides flanking the core E-box motif contribute to the binding specificity of Ascl1 and Neurog2. | Nature Neuroscience

Supplementary Figure 3: Nucleotides flanking the core E-box motif contribute to the binding specificity of Ascl1 and Neurog2.

From: Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes

Supplementary Figure 3

a, Nucleotides flanking the core “CAGNTG” k-mer also contribute to Ascl1 or Neurog2 differential binding (A > N or N > A) and shared binding (A = N) in vivo. b, DNA shape prediction at the Ascl1- and Neurog2-preferred sites around the core E-box motifs. Larger predicted propeller twist and minor groove width were noted at alternate sides of the core E-box motif in Ascl1-preferred sites (A > N).

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