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NEURODEGENERATIVE DISEASE

Senescent glia spell trouble in Alzheimer’s disease

Nature Neurosciencevolume 22pages683684 (2019) | Download Citation

DNA damage or cellular stresses can induce senescence, and increased senescence with aging contributes to age-associated tissue damage, inflammation and disease. Zheng and colleagues report increased senescent oligodendrocyte progenitor cells around amyloid plaques. Therapeutically eliminating these senescent cells may influence the onset and progression of Alzheimer’s disease pathology.

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Author information

Affiliations

  1. Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

    • David Holtzman
    •  & Jason Ulrich

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Competing interests

The authors declare no competing interests.

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Correspondence to David Holtzman.

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https://doi.org/10.1038/s41593-019-0395-2

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