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Anatomical specialties for value information

The ventrolateral and medial orbitofrontal cortices are involved in selecting actions based on the value of expected outcomes. Malvaez and colleagues reveal that these brain regions are specialized in value encoding (ventrolateral orbitofrontal cortices) versus value memory retrieval (medial orbitofrontal cortices) and that they interact with the basolateral amygdala to orchestrate goal-oriented reward-seeking.

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Fig. 1: Anatomical segregation of value information.


  1. Gremel, C. M. & Costa, R. M. Nat. Commun. 4, 2264 (2013).

    Article  Google Scholar 

  2. Bradfield, L. A., Dezfouli, A., van Holstein, M., Chieng, B. & Balleine, B. W. Neuron 88, 1268–1280 (2015).

    Article  CAS  Google Scholar 

  3. Fiuzat, E. C., Rhodes, S. E. & Murray, E. A. J. Neurosci. 37, 2463–2470 (2017).

    Article  CAS  Google Scholar 

  4. Baltz, E. T., Yalcinbas, E. A., Renteria, R. & Gremel, C. M. eLife 7, e35988 (2018).

    Article  Google Scholar 

  5. Malvaez, M. et al. Nat. Neurosci. (2019).

    Article  PubMed  Google Scholar 

  6. Izquierdo, A. J. Neurosci. 37, 10529–10540 (2017).

    Article  CAS  Google Scholar 

  7. Wilson, R. C., Takahashi, Y. K., Schoenbaum, G. & Niv, Y. Neuron 81, 267–279 (2014).

    Article  CAS  Google Scholar 

  8. Swanson, A. M., Allen, A. G., Shapiro, L. P. & Gourley, S. L. Neuropsychopharmacology 40, 1027–1036 (2015).

    Article  CAS  Google Scholar 

  9. Jackson, S. A., Horst, N. K., Pears, A., Robbins, T. W. & Roberts, A. C. Cereb. Cortex 26, 3273–3284 (2016).

    Article  Google Scholar 

  10. Zimmermann, K. S., Yamin, J. A., Rainnie, D. G., Ressler, K. J. & Gourley, S. L. Biol. Psychiatry 81, 366–377 (2017).

    Article  CAS  Google Scholar 

  11. Zimmermann, K. S., Li, C. C., Rainnie, D. G., Ressler, K. J. & Gourley, S. L. Neuropsychopharmacology 43, 373–383 (2018).

    Article  CAS  Google Scholar 

  12. Fuchs, R. A., Evans, K. A., Parker, M. P. & See, R. E. J. Neurosci. 24, 6600–6610 (2004).

    Article  CAS  Google Scholar 

  13. Cosme, C. V., Gutman, A. L., Worth, W. R. & LaLumiere, R. T. Addict. Biol. 23, 16–27 (2018).

    Article  CAS  Google Scholar 

  14. Gourley, S. L., Zimmermann, K. S., Allen, A. G. & Taylor, J. R. J. Neurosci. 36, 4600–4613 (2016).

    Article  CAS  Google Scholar 

  15. Schilman, E. A., Uylings, H. B., Galis-de Graaf, Y., Joel, D. & Groenewegen, H. J. Neurosci. Lett. 432, 40–45 (2008).

    Article  CAS  Google Scholar 

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Correspondence to Shannon L. Gourley.

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Gourley, S.L. Anatomical specialties for value information. Nat Neurosci 22, 685–686 (2019).

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