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Astrocytes usurp neurons as a disease focus

Nature Neuroscience (2019) | Download Citation

Astrocytes are emerging as causal or modulating factors in diverse neurological disorders. Two papers published in Nature Neuroscience in 2007 revealed astrocytes as causally contributing to motor neuron loss in amyotrophic lateral sclerosis, thereby challenging the longstanding neuron-centric view of neurodegenerative disease.

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Affiliations

  1. Neuroscience Institute, NYU School of Medicine, New York, NY, USA

    • Shane A. Liddelow
  2. Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY, USA

    • Shane A. Liddelow
  3. Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    • Michael V. Sofroniew
  4. Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    • Michael V. Sofroniew

Authors

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  2. Search for Michael V. Sofroniew in:

Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Shane A. Liddelow or Michael V. Sofroniew.

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DOI

https://doi.org/10.1038/s41593-019-0367-6

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