Astrocytes are emerging as causal or modulating factors in diverse neurological disorders. Two papers published in Nature Neuroscience in 2007 revealed astrocytes as causally contributing to motor neuron loss in amyotrophic lateral sclerosis, thereby challenging the longstanding neuron-centric view of neurodegenerative disease.
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Liddelow, S.A., Sofroniew, M.V. Astrocytes usurp neurons as a disease focus. Nat Neurosci 22, 512–513 (2019). https://doi.org/10.1038/s41593-019-0367-6
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DOI: https://doi.org/10.1038/s41593-019-0367-6
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