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Common knowledge: shared genetics in psychiatry

Geneticists are pushing for ever-greater sample sizes to gain insight into the genetic variation that contributes to psychiatric disorders. Two new genome-wide association studies leverage this approach to provide broad, population-level perspectives on the genetic basis for major depressive disorder and the shared genetic risk that underlies multiple disorders.

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Fig. 1: Cross-disorder polygenic architecture.


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I thank N. J. Cox, K. S. Kendler, M. C. Aldrich, and T. L. Davis for thoughtful discussion and insightful feedback on this article.

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Correspondence to Lea Karatheodoris Davis.

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Davis, L.K. Common knowledge: shared genetics in psychiatry. Nat Neurosci 22, 331–332 (2019).

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