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Dopamine and diet-induced obesity

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research.

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Fig. 1: Possible pathways from diet to dopamine adaptation.


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Correspondence to Dana M. Small.

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DiFeliceantonio, A.G., Small, D.M. Dopamine and diet-induced obesity. Nat Neurosci 22, 1–2 (2019).

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