Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

HISTORICAL NEWS AND VIEWS: FEEDING BEHAVIOR

Dopamine and diet-induced obesity

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Possible pathways from diet to dopamine adaptation.

References

  1. 1.

    Hoebel, B. G. Am. J. Clin. Nutr. 42 (Suppl.), 1133–1150 (1985).

  2. 2.

    Kelley, A. E. & Berridge, K. C. J. Neurosci. 22, 3306–3311 (2002).

    CAS  Article  Google Scholar 

  3. 3.

    Volkow, N. D. & Wise, R. A. Nat. Neurosci. 8, 555–560 (2005).

    CAS  Article  Google Scholar 

  4. 4.

    Avena, N. M., Rada, P. & Hoebel, B. G. Neurosci. Biobehav. Rev. 32, 20–39 (2008).

    CAS  Article  Google Scholar 

  5. 5.

    Johnson, P. M. & Kenny, P. J. Nat. Neurosci. 13, 635–641 (2010).

    CAS  Article  Google Scholar 

  6. 6.

    Wang, G. J. et al. Lancet 357, 354–357 (2001).

    CAS  Article  Google Scholar 

  7. 7.

    Stice, E., Spoor, S., Bohon, C. & Small, D. M. Science 322, 449–452 (2008).

    CAS  Article  Google Scholar 

  8. 8.

    Stice, E., Yokum, S., Blum, K. & Bohon, C. J. Neurosci. 30, 13105–13109 (2010).

    CAS  Article  Google Scholar 

  9. 9.

    Stice, E., Yokum, S., Burger, K. S., Epstein, L. H. & Small, D. M. J. Neurosci. 31, 4360–4366 (2011).

    CAS  Article  Google Scholar 

  10. 10.

    Babbs, R. K. et al. Physiol. Behav. 121, 103–111 (2013).

    CAS  Article  Google Scholar 

  11. 11.

    Tellez, L. A. et al. Science 341, 800–802 (2013).

    CAS  Article  Google Scholar 

  12. 12.

    Adams, W. K. et al. Eur. J. Neurosci. 42, 3095–3104 (2015).

    Article  Google Scholar 

  13. 13.

    van de Giessen, E. et al. Int. J. Obes. 37, 754–757 (2013).

    Article  Google Scholar 

  14. 14.

    DiFeliceantonio, A. G. et al. Cell Metab. 28, 33–44 (2018).

    CAS  Article  Google Scholar 

  15. 15.

    Sun, X., Luquet, S. & Small, D.M. Trends Cogn. Sci. (2017).

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Dana M. Small.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

DiFeliceantonio, A.G., Small, D.M. Dopamine and diet-induced obesity. Nat Neurosci 22, 1–2 (2019). https://doi.org/10.1038/s41593-018-0304-0

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing