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Dopamine and diet-induced obesity

Nature Neuroscience volume 22, pages 1–2 (2019)Cite this article

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In 2010, Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research.

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Fig. 1: Possible pathways from diet to dopamine adaptation.

References

  1. Hoebel, B. G. Am. J. Clin. Nutr. 42 (Suppl.), 1133–1150 (1985).

  2. Kelley, A. E. & Berridge, K. C. J. Neurosci. 22, 3306–3311 (2002).

    Article  CAS  Google Scholar 

  3. Volkow, N. D. & Wise, R. A. Nat. Neurosci. 8, 555–560 (2005).

    Article  CAS  Google Scholar 

  4. Avena, N. M., Rada, P. & Hoebel, B. G. Neurosci. Biobehav. Rev. 32, 20–39 (2008).

    Article  CAS  Google Scholar 

  5. Johnson, P. M. & Kenny, P. J. Nat. Neurosci. 13, 635–641 (2010).

    Article  CAS  Google Scholar 

  6. Wang, G. J. et al. Lancet 357, 354–357 (2001).

    Article  CAS  Google Scholar 

  7. Stice, E., Spoor, S., Bohon, C. & Small, D. M. Science 322, 449–452 (2008).

    Article  CAS  Google Scholar 

  8. Stice, E., Yokum, S., Blum, K. & Bohon, C. J. Neurosci. 30, 13105–13109 (2010).

    Article  CAS  Google Scholar 

  9. Stice, E., Yokum, S., Burger, K. S., Epstein, L. H. & Small, D. M. J. Neurosci. 31, 4360–4366 (2011).

    Article  CAS  Google Scholar 

  10. Babbs, R. K. et al. Physiol. Behav. 121, 103–111 (2013).

    Article  CAS  Google Scholar 

  11. Tellez, L. A. et al. Science 341, 800–802 (2013).

    Article  CAS  Google Scholar 

  12. Adams, W. K. et al. Eur. J. Neurosci. 42, 3095–3104 (2015).

    Article  Google Scholar 

  13. van de Giessen, E. et al. Int. J. Obes. 37, 754–757 (2013).

    Article  Google Scholar 

  14. DiFeliceantonio, A. G. et al. Cell Metab. 28, 33–44 (2018).

    Article  CAS  Google Scholar 

  15. Sun, X., Luquet, S. & Small, D.M. Trends Cogn. Sci. (2017).

Download references

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Authors and Affiliations

  1. Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA

    Alexandra G. DiFeliceantonio & Dana M. Small

  2. Modern Diet and PhysiologyResearch Center, YaleUniversity, New Haven, CT, USA

    Alexandra G. DiFeliceantonio & Dana M. Small

  3. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Alexandra G. DiFeliceantonio

  4. Department of Psychology, Yale University, New Haven, CT, USA

    Dana M. Small

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  1. Alexandra G. DiFeliceantonio
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  2. Dana M. Small
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Correspondence to Dana M. Small.

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DiFeliceantonio, A.G., Small, D.M. Dopamine and diet-induced obesity. Nat Neurosci 22, 1–2 (2019). https://doi.org/10.1038/s41593-018-0304-0

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