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TDP-43 shapeshifts to encipher FTD severity

TDP-43 forms cytoplasmic aggregates in degenerating neurons of frontotemporal dementia (FTD) patients. Laferrière et al. now establish that TDP-43 assemblies from distinct FTD subtypes have different structures, neurotoxicities, and seeding activities, which correlate with FTD severity. Thus, distinct pathological TDP-43 assemblies akin to prion strains might underpin distinct FTD subtypes.

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Fig. 1: SarkoSpin enables isolation of distinct pathological TDP-43 assemblies from FTLD subtypes that capture disease subtype heterogeneity.


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Correspondence to James Shorter.

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Barbieri, E.M., Shorter, J. TDP-43 shapeshifts to encipher FTD severity. Nat Neurosci 22, 3–5 (2019).

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